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Slc26a5tm4(cre/ERT2)Jnz
Targeted Allele Detail
Nomenclature
Symbol: Slc26a5tm4(cre/ERT2)Jnz
Name: solute carrier family 26, member 5; targeted mutation 4, Jian Zou
MGI ID: MGI:5316514
Synonyms: Prestin-CreERT2
Gene: Slc26a5  Location: Chr5:21810655-21865604 bp, - strand  Genetic Position: Chr5, 9.97 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182720
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting vector was generated using recombineering methods to modify a BAC containing the Slc26a5 (prestin) locus. An IRES-cre/ERT2-frt-neo-frt cassette was inserted after the stop codon in exon 20. The vector was electroporated into TL-1 ES cells to produce knockin mice. When crossed to EGFP reporter mice, cre activity was observed in outer hair cells in the cochlea at P2 with tamoxifen treatment at P0. No reporter signal could be detected in vestibular organs, testis or brain (tissues that express Slc26a5 at low levels.) (J:182720)
Generation of Slc26a5tm4(cre/ERT2)Jnz and Slc26a5tm4.1(cre/ERT2)Jnz alleles.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc26a5     Summary of all recombinase alleles driven by Slc26a5. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc26a5 Mutation:  34 strains or lines available
References
Original:  J:182720 Fang J, et al., Outer hair cell-specific prestin-CreERT2 knockin mouse lines. Genesis. 2012 Feb;50(2):124-31
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory