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Ebf1tm1.1Rug
Targeted Allele Detail
Nomenclature
Symbol: Ebf1tm1.1Rug
Name: early B cell factor 1; targeted mutation 1.1, Rudolf Grosschedl
MGI ID: MGI:5316286
Synonyms: Ebf1fl
Gene: Ebf1  Location: Chr11:44618100-45008096 bp, + strand  Genetic Position: Chr11, 26.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182210
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted around exon 2 and 3, which encode part of the DNA-binding domain. Flp-mediated recombination removed the FRT-flanked neo cassette located downstream of exon 3. (J:182210)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ebf1 Mutation:  26 strains or lines available
Notes
ES cell line = D3V.
References
Original:  J:182210 Gyory I, et al., Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 1;26(7):668-82
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory