Ebf1^tm1.1Rug
Targeted Allele Detail

Summary

• Symbol: Ebf1^tm1.1Rug
• Name: early B cell factor 1; targeted mutation 1.1, Rudolf Grosschedl
• MGI ID: MGI:5316286
• Synonyms: Ebf1^fl
• Gene: Ebf1 Location: Chr11:44508144-44898918 bp, + strand Genetic Position: Chr11, 26.45 cM
• Alliance: Ebf1^tm1.1Rug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182210
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 2 and 3, which encode part of the DNA-binding domain. Flp-mediated recombination removed the FRT-flanked neo cassette located downstream of exon 3. (J:182210)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebf1 Mutation: 73 strains or lines available

Notes

ES cell line = D3V.

References

• Original: J:182210 Gyory I, et al., Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 1;26(7):668-82
• All: 12 reference(s)