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Targeted Allele Detail
Symbol: Cfl2tm1Itl
Name: cofilin 2, muscle; targeted mutation 1, inGenious Targeting Laboratory
MGI ID: MGI:5316051
Synonyms: Cofi
Gene: Cfl2  Location: Chr12:54905594-54909662 bp, - strand  Genetic Position: Chr12, 23.75 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:182571
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to insert a single loxP site upstream of exon 4 and a frt-flanked/floxed neomycin resistance (neo) cassette downstream of exon 4. (J:182571)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cfl2 Mutation:  18 strains or lines available
Original:  J:182571 Agrawal PB, et al., Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet. 2012 May 15;21(10):2341-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory