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Abcb8tm1Hard
Targeted Allele Detail
Nomenclature
Symbol: Abcb8tm1Hard
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8; targeted mutation 1, Hossein Ardehali
MGI ID: MGI:5315860
Synonyms: ABCB8f
Gene: Abcb8  Location: Chr5:24393663-24410054 bp, + strand  Genetic Position: Chr5, 11.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182234
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1 via homologous recombination. (J:182234)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcb8 Mutation:  5 strains or lines available
References
Original:  J:182234 Ichikawa Y, et al., Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4152-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory