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Ror1tm1.1Meg
Targeted Allele Detail
Nomenclature
Symbol: Ror1tm1.1Meg
Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Michael E Greenberg
MGI ID: MGI:5315483
Synonyms: Ror1f
Gene: Ror1  Location: Chr4:100095791-100444765 bp, + strand  Genetic Position: Chr4, 45.71 cM, cytoband C6
Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg H2az2Tg(Wnt1-cre)11Rth/0 embryos exhibit sympathetic axon branching defects

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182150
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels. (J:182150)
Generation of the Ror1tm1.1Meg and Ror1tm1.2Meg alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ror1 Mutation:  5 strains or lines available
References
Original:  J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory