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Targeted Allele Detail
Symbol: Ror1tm1.1Meg
Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Michael E Greenberg
MGI ID: MGI:5315483
Synonyms: Ror1f
Gene: Ror1  Location: Chr4:100095791-100444765 bp, + strand  Genetic Position: Chr4, 45.71 cM, cytoband C6
Ror1tm1.1Meg/Ror1tm1.1Meg Ror2tm1.1Meg/Ror2tm1.1Meg H2az2Tg(Wnt1-cre)11Rth/0 embryos exhibit sympathetic axon branching defects

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:182150
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels. (J:182150)
Generation of the Ror1tm1.1Meg and Ror1tm1.2Meg alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ror1 Mutation:  5 strains or lines available
Original:  J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory