Wnt7a^px-J
Spontaneous Allele Detail

Summary

• Symbol: Wnt7a^px-J
• Name: wingless-type MMTV integration site family, member 7A; postaxial hemimelia Jackson
• MGI ID: MGI:5315307
• Gene: Wnt7a Location: Chr6:91340963-91388335 bp, - strand Genetic Position: Chr6, 40.45 cM
• Alliance: Wnt7a^px-J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutations: Deletion, Single point mutation
• Wnt7a^px-J involves 1 genes/genome features (Wnt7a) View all
• Mutation details: This spontaneous mutation in chromosome 6 has a G-to-A transition at 91,394,552 (GRCm38) causing the replacement of arginine with tryptophan at amino acid 143 (p.R143W), and also has a 23,106 bp intragenic deletion, 91,371,385-91,394,492, that encompasses a portion of exon 3 and removes the 5' end of intron 3 including the splice donor site. (J:188477, J:222308)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt7a Mutation: 25 strains or lines available

References

• Original: J:188477 Dionne L, et al., Postaxial hemimelia Jackson, a new spontaneous mouse mutation in Wnt7a. MGI Direct Data Submission. 2012
• All: 2 reference(s)