Grin2b^tm1.1Jwhe
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1.1Jwhe
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Johannes W Hell
• MGI ID: MGI:5314923
• Synonyms: GluN2B L1298A/R1300Q
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1.1Jwhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181943
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 13 was replaced with one in which nucleotide substitutions (CTGCGCCGG to GCGCGCCAA) results in the amino acid substitution of alanine for leucine at positions 1298 (L1298A) and glutamine for arginine at position 1300 (Q1300R). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 13. (J:181943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 96 strains or lines available

References

• Original: J:181943 Halt AR, et al., CaMKII binding to GluN2B is critical during memory consolidation. EMBO J. 2012 Mar 7;31(5):1203-16
• All: 7 reference(s)