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Transgene Detail
Symbol: Tg(TcraTcrbVP2)1Bkim
Name: transgene insertion 1, Byung S Kim
MGI ID: MGI:5314632
Synonyms: TCR VP2
Transgene: Tg(TcraTcrbVP2)1Bkim  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraTcrbVP2)1Bkim expresses 2 genes
Mutation detailsA T cell line (designated C6.9-VP2) was isolated from the spinal cords of Theiler's murine encephalomyelitis virus (TMEV, BeAn strain) infected SJL/J mice that specifically recognizes the TMEV capsid protein peptide VP274-86. Based on this cell line, a transgenic strain that expresses the VP2-specific regulatory T cell receptor was created. Line 1 was generated. (J:146452)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:146452 Hou W, et al., Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med. 2009 Feb 16;206(2):313-28
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory