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Hesx1tm4.1Jpmb
Targeted Allele Detail
Nomenclature
Symbol: Hesx1tm4.1Jpmb
Name: homeobox gene expressed in ES cells; targeted mutation 4.1, Juan Pedro Martinez Barbera
MGI ID: MGI:5314527
Synonyms: Hesx1eGFP
Gene: Hesx1  Location: Chr14:26716375-26724286 bp, + strand  Genetic Position: Chr14, 16.09 cM, cytoband A3-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181005
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a reporter cassette that contained a floxed EGFP and 5x polyadenylation sites, DTA and FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. (J:181005)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hesx1 Mutation:  11 strains or lines available
References
Original:  J:181005 Andoniadou CL, et al., HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development. 2011 Nov;138(22):4931-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory