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Tg(Myh6-Actc1*R312H)307Iko
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Actc1*R312H)307Iko
Name: transgene insertion 307, Issei Komuro
MGI ID: MGI:5313511
Transgene: Tg(Myh6-Actc1*R312H)307Iko  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Actc1*R312H)307Iko expresses 1 gene
 
Mutation detailsThis transgene expresses the mouse cardiac alpha-actin with a histidine substitution for an arginine at amino acid 312 (R312H) and an HA tag under the control of the murine alpha-myosin heavy chain promoter. Three lines were made, with line 307 the highest expressor. (J:178587)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:178587 Toko H, et al., Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation. 2010 Aug 31;122(9):891-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory