Tg(Myh6-Actc1*R312H)307Iko
Transgene Detail

Summary

• Symbol: Tg(Myh6-Actc1*R312H)307Iko
• Name: transgene insertion 307, Issei Komuro
• MGI ID: MGI:5313511
• Transgene: Tg(Myh6-Actc1*R312H)307Iko Location: unknown
• Alliance: Tg(Myh6-Actc1*R312H)307Iko page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Actc1*R312H)307Iko expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Actc1 (MGI:87905)

• Mutation details: This transgene expresses the mouse cardiac alpha-actin with a histidine substitution for an arginine at amino acid 312 (R312H) and an HA tag under the control of the murine alpha-myosin heavy chain promoter. Three lines were made, with line 307 the highest expressor. (J:178587)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178587 Toko H, et al., Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation. 2010 Aug 31;122(9):891-9
• All: 3 reference(s)