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Targeted Allele Detail
Symbol: Fbn1tm3.1Lysa
Name: fibrillin 1; targeted mutation 3.1, Lynn Y Sakai
MGI ID: MGI:5313326
Synonyms: Fbn1floxed WMdelta
Gene: Fbn1  Location: Chr2:125300594-125506485 bp, - strand  Genetic Position: Chr2, 61.38 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:181493
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 10. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 10. An additional loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neo cassette leaving exons 10 and 11 floxed. (J:181493)
Generation of the Fbn1tm3.1Lysa and Fbn1tm3.2Lysa alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbn1 Mutation:  7 strains or lines available
Original:  J:181493 Sengle G, et al., Microenvironmental regulation by fibrillin-1. PLoS Genet. 2012 Jan;8(1):e1002425
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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