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Fbn1tm3.1Lysa
Targeted Allele Detail
Nomenclature
Symbol: Fbn1tm3.1Lysa
Name: fibrillin 1; targeted mutation 3.1, Lynn Y Sakai
MGI ID: MGI:5313326
Synonyms: Fbn1floxed WMdelta
Gene: Fbn1  Location: Chr2:125300594-125506485 bp, - strand  Genetic Position: Chr2, 61.38 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181493
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 10. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 10. An additional loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neo cassette leaving exons 10 and 11 floxed. (J:181493)
Generation of the Fbn1tm3.1Lysa and Fbn1tm3.2Lysa alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbn1 Mutation:  7 strains or lines available
References
Original:  J:181493 Sengle G, et al., Microenvironmental regulation by fibrillin-1. PLoS Genet. 2012 Jan;8(1):e1002425
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory