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Sqstm1tm1Hwl
Targeted Allele Detail
Nomenclature
Symbol: Sqstm1tm1Hwl
Name: sequestosome 1; targeted mutation 1, Han-Woong Lee
MGI ID: MGI:5313263
Gene: Sqstm1  Location: Chr11:50199366-50210827 bp, - strand  Genetic Position: Chr11, 30.36 cM, cytoband B1.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181228
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, liver and pancreas. (J:181228)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sqstm1 Mutation:  8 strains or lines available
References
Original:  J:181228 Kwon J, et al., Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep. 2012 Feb 1;13(2):150-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory