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Ndfip1tm1Sest
Targeted Allele Detail
Nomenclature
Symbol: Ndfip1tm1Sest
Name: Nedd4 family interacting protein 1; targeted mutation 1, Seong-Seng Tan
MGI ID: MGI:5313245
Synonyms: Ndfip1loxP
Gene: Ndfip1  Location: Chr18:38418912-38465190 bp, + strand  Genetic Position: Chr18, 20.32 cM, cytoband B3
Ndfip1tm1Sest/Ndfip1tm1Sest Tg(Nes-cre)1Kln/0 mice show increased infract size after hypoxia-ischemia

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180657
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. (J:180657)
Generation of the Ndfip1tm1Sest allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ndfip1 Mutation:  6 strains or lines available
References
Original:  J:180657 Howitt J, et al., Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol. 2012 Jan 9;196(1):29-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory