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Targeted Allele Detail
Symbol: Ndfip1tm1Sest
Name: Nedd4 family interacting protein 1; targeted mutation 1, Seong-Seng Tan
MGI ID: MGI:5313245
Synonyms: Ndfip1loxP
Gene: Ndfip1  Location: Chr18:38418912-38465190 bp, + strand  Genetic Position: Chr18, 20.32 cM, cytoband B3
Ndfip1tm1Sest/Ndfip1tm1Sest Tg(Nes-cre)1Kln/0 mice show increased infract size after hypoxia-ischemia

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:180657
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. (J:180657)
Generation of the Ndfip1tm1Sest allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ndfip1 Mutation:  6 strains or lines available
Original:  J:180657 Howitt J, et al., Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. J Cell Biol. 2012 Jan 9;196(1):29-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory