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Transgene Detail
Symbol: Tg(Avil-icre/ERT2)AJwo
Name: transgene insertion A, John N Wood
MGI ID: MGI:5312922
Synonyms: AvCreERT2, Tg(Avil-cre/ERT2)AJwo
Transgene: Tg(Avil-icre/ERT2)AJwo  Location: Chr6:62276099-62638573 bp  Genetic Position: Chr6, Syntenic
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
  Tg(Avil-icre/ERT2)AJwo involves 1 genes/genome features (Ccser1) View all
Mutation detailsBAC recombineering was used to generate a vector with the cre/ERT2 sequence fused with the start codon in exon 2 of a partial advillin gene sequence located in BAC clone RPCI23-424F19. An Frt-flanked kanamycin selection marker was included in the initial cre cassette and was subsequently excised by induction of Flp recombinase in EL250 cells. The purified construct was used for pronuclear injection to generate 8 founder lines. Cre activity was verified in offspring of founders by breeding to ROSA26-lacZ reporter mice. Founder A exhibited strongest staining in DRGs and was analyzed in detail. Line A carries about 10 transgene copies (estimated by Southern blotting.) The transgene has integrated into the intronic region between exons 10 and 11 of the Ccser1 gene on chromosome 6 (chr6: 62276099-62638573). The insertion creates an 82 bp deletion. (J:181671)
 Tissue activity of this recombinase allele
Driver: Avil     Summary of all recombinase alleles driven by Avil. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:181671 Lau J, et al., Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain. 2011;7:100
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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