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Targeted Allele Detail
Symbol: Kdm8tm1.2Tasu
Name: lysine (K)-specific demethylase 8; targeted mutation 1.2, Takeshi Suzuki
MGI ID: MGI:5311834
Synonyms: Jmjd5delta
Gene: Kdm8  Location: Chr7:125444676-125462269 bp, + strand  Genetic Position: Chr7, 68.85 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:181189
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 4 and an FRT flanked inverted neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exon 4. (J:181189)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm8 Mutation:  10 strains or lines available
Original:  J:181189 Ishimura A, et al., Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012 Feb;139(4):749-59
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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