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b2b997Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b997Clo
Name: Mutant line 997; Bench to Bassinet Program (B2B/CVDC), mutation 997 Cecilia Lo
MGI ID: MGI:5311380
Synonyms: Voodoo
Gene: b2b997Clo  Location: unknown  Genetic Position: ChrUN, Syntenic
Mutant 997-006-LA shows heterotaxy indicated by mesocardia, right lung isomerism, and mid-line liver

Show the 10 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b997Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b997Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiovascular defects: Heterotaxy with right pulmonary isomerism and congenital heart disease including transposition of the great arteries (TGA), double outlet right ventricle (DORV), and atrio-ventricular septal defects (AVSD)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0190 Heterotaxy syndrome
0606 DORV + AVSD (AV canal)
0700 D-loop transposition of the great arteries
1132 Unbalanced complete common atrioventricular canal
1140 Common atrium
3804 Congenital heart disease
3817 Abdominal situs ambiguous (abdominal heterotaxy)
3950 {S,D,D}
3983 {A,D,D}
4235 Pulmonary malformation

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory