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Arl6tm2Vcs
Targeted Allele Detail
Nomenclature
Symbol: Arl6tm2Vcs
Name: ADP-ribosylation factor-like 6; targeted mutation 2, Val C Sheffield
MGI ID: MGI:5310744
Synonyms: Bbs3-
Gene: Arl6  Location: Chr16:59612949-59639391 bp, - strand  Genetic Position: Chr16, 34.83 cM, cytoband C1.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180524
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 and 7 were replaced with a neomycin selection cassette. RT-PCR and Western blot analysis confirmed that gene expression of both isoforms waqs disrupted. (J:180524)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Arl6 Mutation:  15 strains or lines available
References
Original:  J:180524 Zhang Q, et al., Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20678-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory