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Akap13tm1Segj
Targeted Allele Detail
Nomenclature
Symbol: Akap13tm1Segj
Name: A kinase (PRKA) anchor protein 13; targeted mutation 1, James H Segars
MGI ID: MGI:5308769
Synonyms: brx-
Gene: Akap13  Location: Chr7:75455534-75754609 bp, + strand  Genetic Position: Chr7, 43.76 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111574
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exon 5, which encodes the Dbl homology (DH) domain. RT-PCR confirmed the absence of transcript expression in embryos. (J:181088)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akap13 Mutation:  113 strains or lines available
References
Original:  J:111574 Kino T, et al., Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. J Biol Chem. 2006 Apr 7;281(14):9118-26
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory