Mcph1tm1.1Zqw
Targeted Allele Detail
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Symbol: |
Mcph1tm1.1Zqw |
Name: |
microcephaly, primary autosomal recessive 1; targeted mutation 1.1, Zhao-Qi Wang |
MGI ID: |
MGI:5308745 |
Synonyms: |
Mcph1delta |
Gene: |
Mcph1 Location: Chr8:18645147-18853205 bp, + strand Genetic Position: Chr8, 10.24 cM, cytoband A3
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Alliance: |
Mcph1tm1.1Zqw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:180706
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neo cassette was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 4 and 5 as well as the neo cassette. Western blot analysis confirmed the absence of protein expression in primary mouse embryonic fibroblasts and the brain.
(J:180706)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mcph1 Mutation: |
58 strains or lines available
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Original: |
J:180706 Gruber R, et al., MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol. 2011 Nov;13(11):1325-34 |
All: |
5 reference(s) |
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