Cfap126tm1.1(icre)Heli
Targeted Allele Detail
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Symbol: |
Cfap126tm1.1(icre)Heli |
Name: |
cilia and flagella associated protein 126; targeted mutation 1.1, Heiko Lickert |
MGI ID: |
MGI:5308442 |
Synonyms: |
1700009P17Riktm1.1(icre)Heli, FltpT2AiCre |
Gene: |
Cfap126 Location: Chr1:170941487-170954536 bp, + strand Genetic Position: Chr1, 78.96 cM
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Alliance: |
Cfap126tm1.1(icre)Heli page
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Cfap126tm1.1(icre)Heli expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A vector was constructed to insert a strept/FLAG-tandem affinity tag (SF-TAG) followed by a T2A peptide sequence (from Thosea asigna virus) and the codon-improved cre recombinase (icre) sequence into exon 6 of the 1700009P17Rik gene (called Flattop; Fltp). An Frt-flanked PGK-neo sequence followed cre in the construct. The targeting vector was introduced into IDG3.2 ES cells for homologous recombination. Southern blotting showed that recombination occurred on the C57BL/6J allele. After germline transmission was established, mice were crossed to Flpe-expressing line to remove the neo cassette.
(J:180887)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cfap126
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cfap126 Mutation: |
15 strains or lines available
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Original: |
J:180887 Lange A, et al., Fltp(T2AiCre): A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues. Differentiation. 2012 Feb;83(2):S105-13 |
All: |
5 reference(s) |
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