Kdm5btm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Kdm5btm1c(EUCOMM)Wtsi |
Name: |
lysine demethylase 5B; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5308434 |
Synonyms: |
Jarid1bF |
Gene: |
Kdm5b Location: Chr1:134487916-134560621 bp, + strand Genetic Position: Chr1, 58.24 cM, cytoband E4
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Alliance: |
Kdm5btm1c(EUCOMM)Wtsi page
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IMPC: |
Kdm5b gene page |
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Mutant Cell Lines: |
EPD0027_1_F07, EPD0027_1_F08 |
Germline Transmission: |
Earliest citation of germline transmission:
J:180267
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 136491938 of Chromosome 1 upstream of the critical exon(s) (Build 37). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 136492740. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele.
(J:155845, J:173534)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kdm5b Mutation: |
198 strains or lines available
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Cell lines EPD0027_1_F07 and EPD0027_1_F08 were successfully used to make chimeric mice. Germline transmission was accomplished. J:180267
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Original: |
J:180267 Schmitz SU, et al., Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J. 2011 Nov 16;30(22):4586-600 |
All: |
8 reference(s) |
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