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Siglechtm1.1Ksat
Targeted Allele Detail
Summary
Symbol: Siglechtm1.1Ksat
Name: sialic acid binding Ig-like lectin H; targeted mutation 1.1, Katsuaki Sato
MGI ID: MGI:5308226
Synonyms: Siglechdtr
Gene: Siglech  Location: Chr7:55417926-55428673 bp, + strand  Genetic Position: Chr7, 33.42 cM
Alliance: Siglechtm1.1Ksat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179283
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA fusion of human DTR and EGFP, an IRES sequence, and a self excising Cre-Neo cassette were inserted in the 3' untranslated region via homologous recombination. Plasmacytoid dendritic cells from homozygous mice are deficient in transcriptional and cell surface expression. (J:179283)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Siglech Mutation:  19 strains or lines available
References
Original:  J:179283 Takagi H, et al., Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo. Immunity. 2011 Dec 23;35(6):958-71
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory