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Tac2tm1.1(cre)Qima
Targeted Allele Detail
Nomenclature
Symbol: Tac2tm1.1(cre)Qima
Name: tachykinin 2; targeted mutation 1.1, Qiufu Ma
MGI ID: MGI:5307922
Synonyms: Tac2-Cre
Gene: Tac2  Location: Chr10:127560347-127567637 bp, + strand  Genetic Position: Chr10, 74.81 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180805
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe cre coding sequence with a poly adenylation signal was inserted in-frame with the first ATG of the Tac2 gene by homologous recombination. The initial targeting vector contained an Frt-flanked neomycin cassette. Germline-transmitting mice were crossed with a Flp deleter strain to excise the neo cassette. Insertion of the cre cassette results in generation of a null allele of Tac2 demonstrated by absence of Tac2 expression in the dorsal spinal cord as detected by in situ hybridization. (J:180805)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tac2     Summary of all recombinase alleles driven by Tac2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tac2 Mutation:  17 strains or lines available
References
Original:  J:180805 Mar L, et al., Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain. 2012;5:3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory