Pdk4^tm1Tok
Targeted Allele Detail

Summary

• Symbol: Pdk4^tm1Tok
• Name: pyruvate dehydrogenase kinase, isoenzyme 4; targeted mutation 1, Toshihisa Komori
• MGI ID: MGI:5307906
• Gene: Pdk4 Location: Chr6:5483351-5496278 bp, - strand Genetic Position: Chr6, 2.06 cM
• Alliance: Pdk4^tm1Tok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179789
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence starting in exon 3 and continuing through the beginning of exon 10 was replaced with an IRES-lacZ and a PGK-gb2-neomycin selection cassette. LacZ expression could not be detected in either heterozygous or homozygous mice. (J:179789)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdk4 Mutation: 30 strains or lines available

References

• Original: J:179789 Wang Y, et al., Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis. Bone. 2012 Jan;50(1):409-19
• All: 1 reference(s)