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Tnfsf11tles
Chemically induced Allele Detail
Nomenclature
Symbol: Tnfsf11tles
Name: tumor necrosis factor (ligand) superfamily, member 11; toothless
MGI ID: MGI:5307891
Synonyms: RANKLG278R
Gene: Tnfsf11  Location: Chr14:78277446-78308043 bp, - strand  Genetic Position: Chr14, 41.26 cM
Mutation
origin
Strain of Origin:  C57BL/6J x 129S6/SvEvTac
Mutation
description
Allele Type:    Chemically induced (ENU) (Dominant negative)
Mutation:    Single point mutation
 
Mutation detailsENU-mutagenesis induced a point mutation (G to A) that results in the amino acid substitution of glycine with arginine at position 278 (p.G278R) in the encoded protein. The predicted protein is a dominant negative form. (J:179743)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf11 Mutation:  25 strains or lines available
References
Original:  J:179743 Douni E, et al., A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 2012 Feb 15;21(4):784-98
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory