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Targeted Allele Detail
Symbol: Brca1tm1.1Jjon
Name: breast cancer 1, early onset; targeted mutation 1.1, Jos Jonkers
MGI ID: MGI:5307254
Synonyms: Brca1C61G
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:178595
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Hypomorph)
Mutations:    Insertion, Single point mutation
Mutation detailsA floxed neo cassette was inserted upstream of exon 5 and a T to G mutation, resulting in a cysteine to glycine substitution at amino acid position 61 (C61G) in a conserved RING domain, was introduced via homologous recombination. Cre mediated recombination removed the neo cassette. (J:178595)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  75 strains or lines available
Original:  J:178595 Drost R, et al., BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance. Cancer Cell. 2011 Dec 13;20(6):797-809
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory