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Tg(Lgi1*)#Mpan
Transgene Detail
Nomenclature
Symbol: Tg(Lgi1*)#Mpan
Name: transgene insertion, Matthew P Anderson
MGI ID: MGI:5307228
Synonyms: mLGI1
Transgene: Tg(Lgi1*)#Mpan  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Lgi1*)#Mpan expresses 1 gene
 
Mutation detailsThis transgene consists of a hemagglutinin-tagged mouse Lgi1 BAC construct containing a premature translational stop codon in exon 6 to reproduce the human autosomal dominant lateral temporal lobe epilepsy mutation 835delC that truncates the C-terminal epitempin repeat and ADAM22-binding domain. (J:154129)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:154129 Zhou YD, et al., Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009 Oct;15(10):1208-14
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory