Grhl3^tm3.1Jane
Targeted Allele Detail

Summary

• Symbol: Grhl3^tm3.1Jane
• Name: grainyhead like transcription factor 3; targeted mutation 3.1, Stephen M Jane
• MGI ID: MGI:5306651
• Synonyms: Grhl3^fl
• Gene: Grhl3 Location: Chr4:135269199-135300941 bp, - strand Genetic Position: Chr4, 67.76 cM
• Alliance: Grhl3^tm3.1Jane page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178952
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:178952)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grhl3 Mutation: 53 strains or lines available

References

• Original: J:178952 Darido C, et al., Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011 Nov 15;20(5):635-48
• All: 4 reference(s)