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Targeted Allele Detail
Symbol: Trp53tm1.1Dgk
Name: transformation related protein 53; targeted mutation 1.1, David G Kirsch
MGI ID: MGI:5306612
Synonyms: p53FRT
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Germline Transmission:  Earliest citation of germline transmission: J:180576
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a FRT site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette followed by a second FRT site downstream of exon 6. Cre-mediated recombination removed the neo cassette. (J:180576)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  158 strains or lines available
Original:  J:180576 Lee CL, et al., Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. Dis Model Mech. 2012 May;5(3):397-402
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory