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Targeted Allele Detail
Symbol: Slc6a12tm1.1Ncd
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; targeted mutation 1.1, NC Danbolt
MGI ID: MGI:5306247
Synonyms: BGT1-flox
Gene: Slc6a12  Location: Chr6:121343076-121365775 bp, + strand  Genetic Position: Chr6, 57.25 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:180428
Parent Cell Line:  D1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream to exon 3. A FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exons 3 through 5 floxed. (J:180428)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a12 Mutation:  30 strains or lines available
Original:  J:180428 Lehre AC, et al., Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011 Jun;95(1-2):70-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory