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Targeted Allele Detail
Symbol: Igf1rtm2.1Arge
Name: insulin-like growth factor I receptor; targeted mutation 2.1, Argiris Efstratiadis
MGI ID: MGI:5306047
Gene: Igf1r  Location: Chr7:67952827-68233668 bp, + strand  Genetic Position: Chr7, 37.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:178908
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was flanked by a floxed neo cassette in intron 2 and a single loxP site in intron 3. Subsequently, properly targeted mice were crossed to cre expressing mis leading to germ line excision of exon 3. (J:60711)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:  49 strains or lines available
Original:  J:178908 Okano T, et al., Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci. 2011 Dec 7;31(49):18104-18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory