Tg(IGHMdeltaV)6Corc
Transgene Detail

Summary

• Symbol: Tg(IGHMdeltaV)6Corc
• Name: transgene insertion 6, Daniel Corcos
• MGI ID: MGI:5305989
• Synonyms: delta-V mu 6, deltaVmu-6
• Transgene: Tg(IGHMdeltaV)6Corc Location: unknown
• Alliance: Tg(IGHMdeltaV)6Corc page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2 or (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGHMdeltaV)6Corc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGHM (3507)

  Ighm	(MGI:96448)

• Mutation details: The deltaVmu transgene construct was derived from a rearranged human mu immunoglobulin heavy-chain gene by joining the V-segment leader (L) exon directly to an 11-kb fragment containing the mu constant region (Cmu) exons, deleting the V(D)J exon. This transgene encodes both secreted and membrane bound Cmu protein. Transgene-derived mRNA is detected at high levels in spleen and thymus, but not in brain, liver or kidney of mice of this transgenic line. Human immunoglobulin mu (IGmu) heavy chains are detected by ELISA in the sera of these mice. Spleen cells can be identified by FCM analysis that express both the B cell lineage-specific marker, B220, and the truncated human IGmu chain on their surfaces. In this line, the human IGmu is also expressed by a population of B220^- cells that lack the T cell-specific Thy-1 marker express, as well. (J:135417)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This is the only one of seven mouse lines derived from nine transgenic mice generated using this construct whose analysis is reported in detail. (J:135417)

References

• Original: J:135417 Corcos D, et al., Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein. Eur J Immunol. 1991 Nov;21(11):2711-6
• All: 4 reference(s)