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Tg(Thy1-MAPT*)3610Gds
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT*)3610Gds
Name: transgene insertion 3610, Gerard Schellenberg
MGI ID: MGI:5305849
Synonyms: E391-3610, THY1.2::TauE391
Transgene: Tg(Thy1-MAPT*)3610Gds  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT*)3610Gds expresses 1 gene
 
Mutation detailsThe transgenic construct contains the 4R1N tau isoform truncated at amino acid position E391(glutamic acid) and under the direction of the Thy1b (Thy1.2) neuron specific promoter. The construct contains sequences encoded by alternatively spliced exons 2 and 10 and has 4 microtubule repeats. Lines 3608 and 3610 was generated. (J:179578)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:179578 McMillan PJ, et al., Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011 Nov;70(11):1006-19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory