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Gaktm2Legr
Targeted Allele Detail
Nomenclature
Symbol: Gaktm2Legr
Name: cyclin G associated kinase; targeted mutation 2, Lois E Greene
MGI ID: MGI:5305733
Synonyms: GAKfl
Gene: Gak  Location: Chr5:108569411-108629755 bp, - strand  Genetic Position: Chr5, 53.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180119
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. (J:180119)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gak Mutation:  45 strains or lines available
References
Original:  J:180119 Lee DW, et al., Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Mol Biol Cell. 2008 Jul;19(7):2766-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory