Tg(PDGFRA-lacZ)2.2-07Nist
Transgene Detail

Summary

• Symbol: Tg(PDGFRA-lacZ)2.2-07Nist
• Name: transgene insertion 2.2-07, Monica Nister
• MGI ID: MGI:5305726
• Synonyms: Line 2.2-07, PDGFR-alpha promoter-lacZ, PDGFRAprom-2.2-lacZ-0.7, PDGFRA-promoter-lacZ transgene, Transgenic line 2.2-07
• Transgene: Tg(PDGFRA-lacZ)2.2-07Nist Location: unknown
• Alliance: Tg(PDGFRA-lacZ)2.2-07Nist page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: This transgenic mouse line expresses beta-galactosidase from the E. coli lacZ coding sequence under control of 2.2 kb of 5' flanking sequence, encompassing nucleotides -2120 to +129, of the human platelet derived growth factor receptor, alpha polypeptide (PDGFRA) gene. Expression of the transgene, visualized by X-gal staining, in mesoderm- and neural crest-derived tissues of the developing mouse embryo is similar to that of endogenous Pdgfra mRNA detected by in situ hybridization using mouse specific probes. An exception is in the neural tube and brain, where beta-galactosidase activity, but not Pdgfra transcription, is observed. (J:46139)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:46139 Zhang XQ, et al., Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene. Mech Dev. 1998 Jan;70(1-2):167-80
• All: 1 reference(s)