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Tg(PDGFRA-lacZ)2.2-07Nist
Transgene Detail
Nomenclature
Symbol: Tg(PDGFRA-lacZ)2.2-07Nist
Name: transgene insertion 2.2-07, Monica Nister
MGI ID: MGI:5305726
Synonyms: Line 2.2-07, PDGFR-alpha promoter-lacZ, PDGFRAprom-2.2-lacZ-0.7, PDGFRA-promoter-lacZ transgene, Transgenic line 2.2-07
Transgene: Tg(PDGFRA-lacZ)2.2-07Nist  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsThis transgenic mouse line expresses beta-galactosidase from the E. coli lacZ coding sequence under control of 2.2 kb of 5' flanking sequence, encompassing nucleotides -2120 to +129, of the human platelet derived growth factor receptor, alpha polypeptide (PDGFRA) gene. Expression of the transgene, visualized by X-gal staining, in mesoderm- and neural crest-derived tissues of the developing mouse embryo is similar to that of endogenous Pdgfra mRNA detected by in situ hybridization using mouse specific probes. An exception is in the neural tube and brain, where beta-galactosidase activity, but not Pdgfra transcription, is observed. (J:46139)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:46139 Zhang XQ, et al., Specific expression in mouse mesoderm- and neural crest-derived tissues of a human PDGFRA promoter/lacZ transgene. Mech Dev. 1998 Jan;70(1-2):167-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory