Krt5^{tm1.1(cre/ERT2)Blh}
Targeted Allele Detail

Summary

• Symbol: Krt5^{tm1.1(cre/ERT2)Blh}
• Name: keratin 5; targeted mutation 1.1, Brigid L Hogan
• MGI ID: MGI:5305438
• Synonyms: K5-CreER^T2, Krt5^tm1.1Blh
• Gene: Krt5 Location: Chr15:101615505-101621333 bp, - strand Genetic Position: Chr15, 56.98 cM
• Alliance: Krt5^{tm1.1(cre/ERT2)Blh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Krt5^{tm1.1(cre/ERT2)Blh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt5 (MGI:96702)

• Mutation details: An IRES-cre/ERT2 fragment was inserted into the 3'UTR of the Krt5 gene along with an FRT flanked neomycin selection cassette. The selection cassette was subsequenty excised from properly targeted mice using flp recombinase. (J:180048)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt5 (mouse) Summary of all recombinase alleles driven by Krt5. Alliance mouse Krt5 gene page

Tumor Data

List all tumor models in MMHCdb carrying Krt5^{tm1.1(cre/ERT2)Blh}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Krt5 Mutation: 13 strains or lines available

References

• Original: J:180048 Van Keymeulen A, et al., Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011 Nov 10;479(7372):189-93
• All: 38 reference(s)