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Tg(Krt8-cre/ERT2)17Blpn
Transgene Detail
Nomenclature
Symbol: Tg(Krt8-cre/ERT2)17Blpn
Name: transgene insertion 17, Cedric Blanpain
MGI ID: MGI:5305437
Synonyms: K8-CreER, K8- CreERT2
Transgene: Tg(Krt8-cre/ERT2)17Blpn  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA transgene construct containing 3.5 kb of sequence upstream of the ATG start site of the mouse Krt8 gene (purified from BAC clone RP23-254K21), the beta globin intron, SV40 polyadenylation site and a cre/ERT2 segment was injected into C57Bl/6 fertilized eggs. Four of seven founder mice displayed the expected pattern of expression and Founder line 17 was subsequently established. The transgenic animals were then bred to CD1 mice. (J:180048)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Krt8     Summary of all recombinase alleles driven by Krt8. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:180048 Van Keymeulen A, et al., Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011 Nov 10;479(7372):189-93
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory