Eif2s3x^{tm2a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Eif2s3x^{tm2a(EUCOMM)Hmgu}
• Name: eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5304882
• Gene: Eif2s3x Location: ChrX:93232315-93256257 bp, - strand Genetic Position: ChrX, 41.52 cM, cytoband C-D
• IMPC: Eif2s3x gene page

Mutation origin

• Mutant Cell Lines: HEPD0786_3_A05, HEPD0786_3_A08, HEPD0786_3_B07, HEPD0786_3_B08, HEPD0786_3_D06, HEPD0786_3_D07, HEPD0786_3_D08, HEPD0786_3_E07, HEPD0786_3_F07, HEPD0786_3_F08, HEPD0786_3_G06, HEPD0786_3_G07, HEPD0786_3_H05, HEPD0786_3_H08
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 93252644 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 93253755. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2s3x Mutation: 6 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)