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Rr175tm1.1Mema
Targeted Allele Detail
Summary
Symbol: Rr175tm1.1Mema
Name: regulatory region 175; targeted mutation 1.1, Masatsugu Ema
MGI ID: MGI:5304851
Synonyms: Flk1-DMME KO, Kdrtm1.1Mema
Gene: Rr175  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance: Rr175tm1.1Mema page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178675
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified regulatory region)
Mutation:    Intragenic deletion
 
Mutation detailsA LoxP and FRT ste flanked neomycin resistance gene cassette replaced the Distal Multipotent Mesodermal Enhancer (DMME), located 27 kb upstream of the TSS of the Kdr gene, via homologous recombination. Cre-mediated recombination removed the neo cassette. Quantitative RT-PCR and immunohistochemical analyses indicate that expression is reduced at E7.5 in homozygous embryos. (J:178675)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr175 Mutation:  0 strains or lines available
References
Original:  J:178675 Ishitobi H, et al., Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse. Development. 2011 Dec;138(24):5357-68
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory