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Targeted Allele Detail
Symbol: Ptpn2tm1.1Ttig
Name: protein tyrosine phosphatase, non-receptor type 2; targeted mutation 1.1, Tony Tiganis
MGI ID: MGI:5304815
Synonyms: Ptpn2fl, Ptpn2lox
Gene: Ptpn2  Location: Chr18:67665511-67724595 bp, - strand  Genetic Position: Chr18, 40.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:179621
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 5 and 6 floxed. (J:179621)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn2 Mutation:  24 strains or lines available
Original:  J:179621 Loh K, et al., Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011 Nov 2;14(5):684-99
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory