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Tg(RP11-209M4)#Gglo
Transgene Detail
Nomenclature
Symbol: Tg(RP11-209M4)#Gglo
Name: transgene insertion, Gabriela G Loots
MGI ID: MGI:5304449
Synonyms: SOST TG, SOSTwt
Transgene: Tg(RP11-209M4)#Gglo  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(RP11-209M4)#Gglo expresses 1 gene
 
Mutation detailsThe transgene contains the wild-type human BAC RP11-209M4, which contains SOST and the 3' end of MEOX. Three lines were generated (A, B, and an unnamed line). RT-PCR and quantitative PCR confirmed that all lines express human SOST in the mineralized bone of neonatal and adult mice (skull, rib, and femur) and in the adult kidney. No expression of human MEOX was detected. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:99965)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99965 Loots GG, et al., Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005 Jul;15(7):928-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory