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Ccne1tm2.1Pisc
Targeted Allele Detail
Nomenclature
Symbol: Ccne1tm2.1Pisc
Name: cyclin E1; targeted mutation 2.1, Piotr Sicinski
MGI ID: MGI:5304316
Synonyms: Cyclin E1Ntag
Gene: Ccne1  Location: Chr7:38097984-38107490 bp, - strand  Genetic Position: Chr7, 25.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178882
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to replace the start codon of the cyclin E1 (Ccne1) gene with a Flag-HA tag. A loxP-flanked hygromycin (hyg) selection cassette was inserted downstream of exon 3. Cre-mediated recombination removed the hygro cassette. (J:178882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccne1 Mutation:  4 strains or lines available
References
Original:  J:178882 Odajima J, et al., Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory