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Il20ratm1.1Misc
Targeted Allele Detail
Nomenclature
Symbol: Il20ratm1.1Misc
Name: interleukin 20 receptor, alpha; targeted mutation 1.1, Ming-Shi Chang
MGI ID: MGI:5302406
Gene: Il20ra  Location: Chr10:19588318-19635801 bp, + strand  Genetic Position: Chr10, 8.76 cM
Il20ratm1.1Misc/Il20ratm1.1Misc mice are protected from ovariectomy-induced bone loss

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177783
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:177783)
Generation of the Il20ratm1.1Misc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il20ra Mutation:  20 strains or lines available
References
Original:  J:177783 Hsu YH, et al., Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011 Aug 29;208(9):1849-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory