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Crbntm1.2Jjh
Targeted Allele Detail
Nomenclature
Symbol: Crbntm1.2Jjh
Name: cereblon; targeted mutation 1.2, Joseph Higgins
MGI ID: MGI:5302192
Gene: Crbn  Location: Chr6:106780201-106800077 bp, - strand  Genetic Position: Chr6, 49.24 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179427
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Crbntm1.2Jjh removes exons 3 and 4. Quantitative RT-PCR confirmed the absence of transcript expression in hippocampus, neocortex, and cerebellum. (J:179427)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crbn Mutation:  20 strains or lines available
References
Original:  J:179427 Rajadhyaksha AM, et al., Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res. 2012 Jan 15;226(2):428-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory