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Dpp6tm1.1Dahn
Targeted Allele Detail
Nomenclature
Symbol: Dpp6tm1.1Dahn
Name: dipeptidylpeptidase 6; targeted mutation 1.1, Dax A Hoffman
MGI ID: MGI:5302080
Synonyms: DPP6 KO
Gene: Dpp6  Location: Chr5:27022355-27932498 bp, + strand  Genetic Position: Chr5, 12.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178547
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the brain. (J:178547)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dpp6 Mutation:  36 strains or lines available
References
Original:  J:178547 Sun W, et al., DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011 Sep 22;71(6):1102-15
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory