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Targeted Allele Detail
Symbol: Fbxo4tm1.1Jadi
Name: F-box protein 4; targeted mutation 1.1, J Alan Diehl
MGI ID: MGI:5301830
Gene: Fbxo4  Location: Chr15:3965445-3979573 bp, - strand  Genetic Position: Chr15, 1.84 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:178645
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the mammary gland, lung, thymus, spleen, and mouse embryonic fibroblasts. (J:178645)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxo4 Mutation:  13 strains or lines available
Original:  J:178645 Vaites LP, et al., The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol. 2011 Nov;31(22):4513-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory