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Maml3tm1Mkit
Targeted Allele Detail
Nomenclature
Symbol: Maml3tm1Mkit
Name: mastermind like 3 (Drosophila); targeted mutation 1, Motoo Kitagawa
MGI ID: MGI:5301728
Gene: Maml3  Location: Chr3:51685907-52105076 bp, - strand  Genetic Position: Chr3, 22.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178680
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and part of intron 1 were replaced with an inverted neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in embryonic fibroblasts from homozygous mice. (J:178680)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Maml3 Mutation:  18 strains or lines available
References
Original:  J:178680 Oyama T, et al., Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development. 2011 Dec;138(23):5235-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory