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Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ursula Zimber-Strobl
MGI ID: MGI:5301613
Synonyms: Notch2ICflSTOP
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179036
Parent Cell Line:  IDG3.2 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs expresses 1 gene
 
Mutation detailsA construct (5' to 3': a CAGGS promoter, floxed neo stop cassette, the cDNA for the intracellular domain (positions 5253-7583; NM_010928), and an FRT-flanked IRES-CD2 reporter) was inserted into the locus. (J:179036)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:179036 Hampel F, et al., CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood. 2011 Dec 8;118(24):6321-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory