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Tg(tetO-GCaMP2)12IRyu
Transgene Detail
Nomenclature
Symbol: Tg(tetO-GCaMP2)12IRyu
Name: transgene insertion 12I, Ron Yu
MGI ID: MGI:5301601
Transgene: Tg(tetO-GCaMP2)12IRyu  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x FVB)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Reporter)
Mutation:    Insertion
 
Mutation detailsThis transgene contains a calcium-sensing molecule, GCaMP2, under the transcriptional control of the tetracycline-responsive promoter element (tetO). GCaMP2 consists of, from 5' to 3', a 13-residue peptide of myosin light chain kinase (M13), a circularly permutated eGFP interrupted at residue 145, calmodulin (CaM), and a polyA recognition sequence. Mutations resulting in increased brightness (D180Y and V93I), thermal stability (V163A, and S175G) and GFP dimerization prevention (A206K) were introduced. (J:157448, J:179273)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:179273 Yu R, Direct Data Submission 2012/01/17. MGI Direct Data Submission. 2012;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory