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Rc3h1tm1.1Mass
Targeted Allele Detail
Nomenclature
Symbol: Rc3h1tm1.1Mass
Name: RING CCCH (C3H) domains 1; targeted mutation 1.1, Marc Schmidt-Supprian
MGI ID: MGI:5301575
Synonyms: Rc3h1F
Gene: Rc3h1  Location: Chr1:160906418-160974978 bp, + strand  Genetic Position: Chr1, 69.75 cM
Increased spleen size in Rc3h1tm1.1Mass/Rc3h1tm1.1MassCommd10Tg(Vav1-icre)A2Kio/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177784
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 4 through 6 floxed. (J:177784)
Generation of the conditional Rc3h1tm1.1Mass allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rc3h1 Mutation:  32 strains or lines available
References
Original:  J:177784 Bertossi A, et al., Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory